Preparation of Ointments/Cream by Emulsification

Preparation of Ointments or Cream by Emulsification

An emulsion system contains an oil phase, an aqueous phase, and an emulsifying agent.

 

For o/w emulsion systems, the following emulsifying agents are used: 


(i) Water-soluble soap 


(ii) Cetyl alcohol 


(iii) Glyceryl monostearate

 

(iv) Combination of emulsifiers: triethanolamine stearate + cetyl alcohol 


(v) Non-ionic emulsifiers: glyceryl monostearate, glyceryl monooleate, propylene glycol  stearate 


For w/o emulsion creams, the following emulsifiers are used: 


(i) Polyvalent ions e.g. magnesium, calcium, and aluminum are used. 


(ii) Combination of emulsifiers: bees wax + divalent calcium ion 


The viscosity of this type of cream prevents the emulsified phase's coalescence and helps stabilize the emulsion. 


Example: Cold cream 


Procedure:


(i) Water-immiscible components e.g. oils, fats, and waxes are melted together over a water bath (70°C). 


(ii) Aqueous solution of all heat-stable, water-soluble components is heated (70°C). 


(iii) Aqueous solution is slowly added to the melted bases with continuous stirring until the product cools down and a semi-solid mass is obtained. 


Note: The aqueous phase is heated otherwise, with a high melting point fats and waxes will immediately solidify with the addition of a cold aqueous solution.

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