Applications of Therapeutic Drug Monitoring

Applications of Therapeutic Drug Monitoring

1. Monitoring of certain drugs theophylline, valproic acid, and methotrexate is associated with increased efficacy and decreased incidences and side effects. 

2. Monitoring determines the safety of the dosage regimen. If the serum concentration is outside the therapeutic range, drug concentration measurements are not required.  As a response to the drug such as; amino-glycoside antibiotics, varies from patient to patient, precision is not maintained due to empiric dosing. 

3. Appropriate interpretation of drug concentration measurements is used in the monitoring for dosage adjustment that minimizes the proportion of patients with serum concentration outside the therapeutic range. 

4. Monitoring encourages professional interactions between members of the health teams such as physicians and pharmacists. 

5. It provides an opportunity for a clinical pharmacist to excel in therapeutic challenges and to work as a vital segment of the health team in the area of pharmacotherapeutics. 

6. It provides additional input in pharmacotherapy. For example; 

  • Evaluation of medication by dosing modification in patients with impaired renal function. 
  • Selection of antibiotics, e.g. aminoglycoside antibiotics by empiric dosing or culture and sensitivity testing. 

7. It is used to develop a dosing protocol that will avoid non-optimum initial therapy. 

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